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Global Infectious Disease Situation Update

Reporting Period: April 20–28, 2026

The AeroClenz Chief Medical Officer periodically reviews publicly available infectious disease surveillance reports from organizations such as the Centers for Disease Control and Prevention (CDC), World Health Organization (WHO), and European Centre for Disease Prevention and Control (ECDC).

These summaries are intended to provide general awareness of global infectious disease activity relevant to international travel, healthcare systems, and high-traffic indoor environments.

This information is provided for situational awareness only and does not constitute medical advice.

Key Takeaways

For the period of April 20–28, 2026, several notable global infectious disease trends were observed:

• Measles continues to present a significant disruption risk due to ongoing outbreaks and high transmissibility
• Seasonal respiratory virus activity is declining globally
• Cholera remains a serious concern in infrastructure-limited regions
• Foodborne and One Health-related signals remain relevant
• Arboviral diseases continue to represent travel-associated risks

Top 5 Signals

1) Measles remains the highest disruption risk per case

Recent reporting indicates continued high measles activity in 2026, with 1,792 U.S. cases reported as of April 23.

A recently concluded outbreak in South Carolina highlights the broader impact of measles events, including prolonged disruption, quarantine requirements, and public-health response demands.

2) Respiratory virus activity continues to decline

WHO’s most recent update indicates:

• Influenza positivity below 10% globally
• SARS-CoV-2 activity remains low
• RSV activity stable at low levels

Influenza B now represents a larger proportion of remaining detections as the seasonal trend continues downward.

3) Cholera remains a multi-country concern

WHO continues to report cholera activity across multiple regions, with 18,715 cases and 269 deaths reported in February 2026, including a notable increase in mortality compared to January.

Cholera transmission remains closely linked to water, sanitation, and healthcare access conditions.

4) Additional public-health signals remain active

Recent reporting highlights additional areas of monitoring beyond respiratory illness, including:

• Avian influenza activity in animal populations
• Foodborne illness signals such as Salmonella

These developments underscore the importance of continued awareness across multiple public-health domains.

5) Arboviruses remain relevant for travelers

Dengue continues to represent a significant burden, with over 624,000 suspected cases reported in the Americas by early 2026, despite being lower than the same period in 2025.

Mosquito-borne diseases, including chikungunya and dengue, remain important considerations for travel-related exposure.

Global Situation Overview

Measles

Measles remains one of the most impactful infectious diseases in this update due to:

• High transmissibility
• Amplification through travel and congregate settings
• Resource-intensive response requirements

Recent outbreak data continues to demonstrate the potential for significant operational and public-health impact from individual cases.

Respiratory Viruses

The global respiratory disease picture continues to improve following peak seasonal activity.

WHO reports:

• Declining influenza detections globally
• Influenza positivity below 10%
• Low SARS-CoV-2 activity
• Stable, low RSV activity

These trends are consistent with a de-escalating seasonal pattern.

Cholera

Cholera remains a serious concern in regions where water, sanitation, and healthcare systems are under strain.

Recent data indicate that mortality has increased more sharply than case counts, suggesting ongoing challenges related to access to care and disease severity in affected areas.

Foodborne and One Health Signals

Public-health reporting continues to monitor additional risks beyond respiratory disease.

Avian influenza remains under surveillance globally, with activity primarily associated with animal populations and limited human cases.

Foodborne illness signals, including Salmonella, highlight the continued importance of food safety and supply chain awareness in public-health monitoring.

Mpox

Mpox continues to be monitored globally, including reporting on clade-specific activity and transmission patterns.

Current risk assessments remain focused on defined populations with specific exposure risks, while overall risk to the general population remains low.

Arboviruses: Dengue and Chikungunya

Dengue remains a significant global burden, particularly in the Americas, despite lower case counts compared to 2025.

Chikungunya and other mosquito-borne diseases continue to be relevant for travel-related exposure, with public-health agencies emphasizing mosquito bite prevention and awareness.

High-Consequence Pathogens

High-consequence pathogens continue to be monitored globally.

Avian influenza (H5):
Widespread in animal populations, with limited human infections and low current public-health risk.

Nipah virus:
Recent cases remain limited, with no evidence of sustained transmission.

Ebola and Marburg viruses:
No active outbreaks are currently reported. Previous outbreaks have been declared contained following appropriate monitoring periods.

Summary

The global infectious disease landscape for late April 2026 reflects declining respiratory virus activity alongside continued monitoring of high-impact and travel-associated risks.

Key themes include:

• Measles is the most significant disruption risk per individual case
• Continued decline in seasonal respiratory virus activity
• Persistent cholera transmission in infrastructure-limited regions
• Ongoing relevance of foodborne and One Health-related signals
• Continued importance of arboviral diseases in travel settings

Public-health surveillance agencies continue to monitor these developments and publish updates as new information becomes available.

Sources referenced in this summary include the Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO), the European Centre for Disease Prevention and Control (ECDC), and peer-reviewed literature, including the Journal of Travel Medicine.

To learn more about AeroClenz, visit www.aeroclenz.com. Follow AeroClenz on social media for updates on research and technology developments.LinkedIn: https://www.linkedin.com/company/aeroclenz
Facebook: https://www.facebook.com/AeroClenz
Instagram: https://www.instagram.com/aeroclenz_

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Michael Stroup

Chief Operations Officer

Michael is a results-driven leader with 20 years of experience improving operations to achieve greater organizational effectiveness, productivity, and performance across multiple industries. Most recently Michael served as Integration Engineering Manager at CooperSurgical, a leading fertility medical device manufacturer. Prior to CSI, he has a proven track record of driving operational and engineering excellence within medical device, food, electronics and automotive industries by leading day to day operations and providing effective strategic leadership/execution.  His expertise includes, but is not limited to, global production set up, process improvements, machinery design and compliance. Michaels holds a Bachelor of Science in Mechanical Engineering Technology and Industrial Automotive Technology from Indiana State University and a Master of Science in Industrial Technology from Indiana State University.

Matt Saberton

CEO, Founder, Co-Inventor

Matt has been passionate about aviation from a young age, earning his private pilot’s license in high school. After obtaining a degree in Aviation and Aerospace Science, he began his career as a flight instructor and then became an air ambulance pilot, where he recognized the importance of cabin cleanliness.

Rising through the ranks at one of the largest worldwide charter airlines, Matt became Captain and later Chief Pilot, gaining deep insights into maintaining safe environments in aviation. This experience led him to found Aeroclenz, Inc., where he now serves as CEO.

Under his leadership, Aeroclenz has transitioned from an aerospace-focused company to a leader in UV disinfection solutions, offering custom products for both aerospace and terrestrial indoor applications. While the company’s roots are in aviation, its technologies now ensure high standards of cleanliness across various industries.

Jameson Trettenero

Director of Marketing

Jameson is a seasoned marketing expert with experience driving strategic marketing initiatives across a diverse array of industries. In his role, Jameson leads the marketing efforts with a focus on innovative growth strategies, brand elevation, and data-driven decision-making that align with the company’s overarching business goals.

Before joining Aeroclenz, Jameson held key leadership positions at top-tier digital agencies. In his agency experience, he spearheaded multi-divisional teams across disciplines including SEO, Paid Media, Analytics, and Creative. His strategic oversight and client-centric approach significantly enhanced client retention and business growth, particularly across enterprise-level accounts.

Jameson’s expertise extends to managing complex client relationships, advising C-level executives, and navigating the intricacies of the marketing landscape. His ability to harmonize creativity with analytics has consistently driven measurable success for clients, from Fortune 500 companies to emerging brands.